Much like the reduction/eradication of most infectious diseases (which vaccines try to take credit for), improved hygiene is the best weapon against the Superbug:
The campaign to improve
hand hygiene in hospitals in England and Wales contributed to a
significant fall in the rates of superbug infections, according to a
report.
The study
published on the BMJ website showed the amount of soap and hand gel being used tripled during the campaign.
At the same time, levels of MRSA and C. difficile infections in hospitals fell.
Hospital superbugs were once a real fear for many patients. In response the
Clean Your Hands campaign, funded by the Department of Health, was introduced in all hospitals by June 2005.
Alcohol gels were put by bedsides, posters reminded staff to
wash their hands and there were regular checks to ensure hands were kept
clean.
By 2008, the total amount of soap and alcohol gel being
purchased by hospitals trebled, going from 22ml per patient per day to
60ml per patient per day.
Rates of MRSA more than halved in the same time period and C. diff infections fell by more than 40%.
Read more:
http://www.bbc.co.uk/news/health-17942182